Mesial temporal sclerosis

Advanced treatment, close to home

Mesial temporal sclerosis is closely related to temporal lobe epilepsy, a type of partial (focal) epilepsy in which the seizure initiation point can be identified within the temporal lobe of the brain. Mesial temporal sclerosis is the loss of neurons and scarring of the deepest portion of the temporal lobe and is associated with certain brain injuries.

Brain damage from traumatic injury, infection, a brain tumor, a lack of oxygen to the brain, or uncontrolled seizures is thought to cause the scar tissue to form, particularly in the hippocampus, a region of the temporal lobe. The region begins to atrophy; neurons die and scar tissue forms. This damage is thought to be a significant cause of temporal lobe epilepsy. In fact, 70 percent of temporal lobe epilepsy patients have some degree of mesial temporal sclerosis. It also appears that the mesial temporal sclerosis can be worsened by additional seizures.



Mesial temporal sclerosis usually causes partial (focal) epilepsy. This seizure disorder can cause a variety of symptoms such as strange sensations, changes in behavior or emotions, muscle spasms, or convulsions. The seizures usually are localized in the brain, but they may spread to become generalized seizures, which involve the entire brain and may cause a sudden loss of awareness or consciousness.


Treatment is aimed at controlling seizures. Treatment for epilepsy resulting from mesial temporal lobe sclerosis typically involves medical and surgical therapy. Anticonvulsant (anti-seizure) medications are typically used to treat this disorder.

Surgical therapy involves either temporal lobectomy or vagus nerve stimulation (VNS). Temporal lobectomy has been proven to be superior to prolonged medical therapy in patients with temporal lobe epilepsy. Vagus nerve stimulation may be used as an aid in reducing seizure frequency in patients with partial onset epilepsy.


Our comprehensive and multi-disciplinary programs provide superior, world-class Mesial temporal sclerosis treatment .

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